Research Progress on Traditional Chinese Medicine Regulating Type H Vessels to Promote Bone Repair

Author：WANG Xingfei1, ZHOU Lewei2, SHI Tengbo1, GUO Chaowei3, TANG Yanfeng3, ZHOU Wenjing4, LI Jitian3, LIU Youwen3

Unit：1.College of Orthopedics and Traumatology, Henan University of Chinese Medicine, Zhengzhou Henan 450000, China; 2.The Affiliated Hospital of Shanxi University of Chinese Medicine, Taiyuan Shanxi 030000, China; 3.Luoyang Orthopedic-Traumatological Hospital (Henan Orthopedic Hospital), Luoyang Henan 471002, China; 4.Shanxi University of Chinese Medicine, Jinzhong Shanxi 030619, China

Quote：引用：王幸飞，周乐炜，石腾博，郭超韡，倘艳锋，周文静，李记天，刘又文.中医药调控H型血管促进骨修复的研究进展[J].中医药导报,2025,31(11):121-126.

DOI：10.13862/j.cn43-1446/r.2025.11.022

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Abstract：This review summarizes the biological characteristics of type H vessels and their regulatory networks [platelet-derived growth factor BB (PDGF-BB), hypoxia-inducible factor-1α (HIF-1α)/vascular endothelial growth factor (VEGF), Slit guidance ligand 3 (SLIT3), and the Notch signaling pathway], and summarizes the molecular mechanisms by which Traditional Chinese Medicine (TCM) promotes bone repair through multi-target interventions in type H vessel formation. As a specialized capillary subtype, type H vessels play a core role in bone repair through the angiogenesis-osteogenesis coupling mechanism. TCM monomers such as total flavonoids of Drynaria fortunei and naringin, as well as compound formulations such as Wenyang Bushen Formula （温阳补肾方) and Shenggu Zaizao Pill (生骨再造丸), can increase type H vessel density and enhance the osteogenesis-angiogenesis coupling effect by activating the PDGF-BB or HIF-α/VEGF signaling axis, regulating the osteoprotegerin (OPG)/receptor activator of nuclear factor kappa-B ligand (RANKL)/receptor activator of nuclear factor kappa-B (RANK) system, and modulating SLIT3 expression. Current research still faces challenges such as ambiguous targets of TCM components, controversy over the source of SLIT3, and insufficient clinical translation.

Key words：type H vessels; angiogenesis-osteogenesis coupling; traditional Chinese medicine; bone repair; signaling pathways

摘要：综述H型血管的生物学特征及其调控网络[血小板衍生生长因子BB（PDGF-BB）、缺氧诱导因子-1α（HIF-1α）/血管内皮生长因子（VEGF）、神经轴突导向因子3（SLIT-3）及Notch信号通路]，并总结中医药通过多靶点干预H型血管形成以促进骨修复的分子机制。H型血管作为特化的毛细血管亚型，可通过成血管-成骨耦联机制在骨修复中发挥核心作用。骨碎补总黄酮、柚皮苷等中药单体以及温阳补肾方、生骨再造丸等复方制剂可通过激活PDGF-BB或HIF-α/VEGF信号轴、调节骨保护素（OPG）/核因子κB受体活化因子配体（RANKL）/核因子κB受体活化因子（RANK）系统及SLIT-3表达，提升H型血管密度并增强成骨-血管耦联效应。当前研究仍面临中药作用靶点模糊、SLIT-3来源争议及临床转化不足等挑战。

关键词：H型血管；成血管-成骨耦联；中医药；骨修复；信号通路

Release time：2025-11-30

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