Discussion on the Mechanism of Diabetes-induced Cognitive Impairment in "Kidney Deficiency and Marrow Reduction" Type Based on Metabolic Reprogramming

Author：ZHANG Mengting1, TAN Aihua1,2, DAI Xinhua1

Unit：1.Huanggang Traditional Chinese Medicine Hospital Affiliated to Hubei University of Chinese Medicine, Huanggang Hubei 438000, China; 2.Beijing University of Chinese Medicine, Beijing 100029, China

Quote：引用：张梦婷，谭爱华，戴新华.基于代谢重编程探讨“肾虚髓减”型糖尿病认知功能障碍的机理[J].中医药导报,2025,31(1):158-163.

DOI：10.13862/j.cn43-1446/r.2025.01.028

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Abstract：

Metabolic reprogramming represents a pivotal pathological mechanism underlying diabetes-induced cognitive impairment (DCI). From the perspective of metabolic reprogramming, based on current clinical and basic research, this paper discusses the mechanism of kidney deficiency and marrow reduction syndrome in patients with DCI. In traditional Chinese medicine, kidney deficiency and marrow reduction are regarded as a common pathological mechanism underlying various brain diseases. Metabolic reprogramming, which is characterised by metabolic disorders and a reduction in cellular energy supply, is believed to be a key factor in the development of cognitive impairment. The pathogenesis of DCI with kidney deficiency and marrow reduction type may lie in the metabolic reprogramming of brain cells dependent on HPA axis regulation based on kidney essence. The traditional Chinese medicine method of tonifying kidney and essence has been demonstrated to reverse metabolic reprogramming to a certain extent and improve DCI.

Key words：diabetes-induced cognitive impairment; kidney deficiency and marrow reduction; metabolic reprogramming; traditional Chinese medicine; theoretical discussion

摘要：

代谢重编程为糖尿病认知功能障碍的重要病理机制。从代谢重编程的角度出发，基于现阶段临床及基础研究，探讨糖尿病认知功能障碍患者肾虚髓减证的机理。肾虚髓减为中医脑病的共同病机，代谢重编程以代谢紊乱、细胞能量供应失衡为特点，贯穿于认知障碍始终。肾虚髓减型糖尿病认知功能障碍的发病机理可能在于以肾精为基础的依赖HPA轴调控的脑细胞代谢重编程。中医补肾益精法可在一定程度上逆转代谢重编程，改善糖尿病认知功能障碍。

关键词：糖尿病认知功能障碍；肾虚髓减；代谢重编程；中医药；理论探讨

Release time：2025-12-01

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