Optimization of Extraction Conditions for Dachengqi Decoction (大承气汤) Based on AHP-EWM Composite Weighting Method and Response Surface Methodology
Author：XU Yanrui1, LI Zheng2, XIAO Yao1, JIANG Yani1, WANG Yanmin1, ZHANG Zhenhong1, WANG Jingjuan1
Unit：1.School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 102488, China; 2.Beijing Institute for Drug Control, Beijing 102206, China
Quote：引用：徐艳蕊，李铮，肖瑶，江垭霓，王艳敏，张振鸿，王晶娟.基于AHP-EWM复合加权法和中心组合设计-响应面法优化大承气汤提取工艺[J].中医药导报,2025,31(3):77-82.
DOI：10.13862/j.cn43-1446/r.2025.03.013
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Abstract：Objective: To optimize the extraction process of
Dachengqi Decoction. Methods: The contents of 10 components, including
magnolol, honokiol, rhein, emodin, aloe-emodin, chrysophanol, naringin,
hesperidin, neohesperidin, and hesperetin, were determined by high-performance
liquid chromatography (HPLC). The content of these components and the extract
yield were used as evaluation indicators. The weight coefficients of each
indicator were determined using the analytic hierarchy process (AHP)-entropy
weight method (EWM) composite weighting. The extraction process of Dachengqi Decoction
was optimized using central composite design (CCD)-response surface methodology
(RSM). Results: The methodological investigation met all requirements. The
optimal extraction process for Dachengqi Decoction was determined as follows:
add 8 times the amount of water to Houpu (Magnolia officinalis) and Zhishi
(Citrus aurantium) decoction pieces, soak for 30 minutes, extract for 1 hour,
and filter. Pour the filtrate into Dahuang (Rheum palmatum) decoction pieces,
soak for 20 minutes, extract for 20 minutes, and filter. Add 6 times the amount
of water to the residue of Houpu (Magnolia officinalis) and Zhishi (Citrus
aurantium), extract for 1 hour, pour the filtrate into the residue of Dahuang
(Rheum palmatum), extract for 20 minutes, and filter. Combine the two filtrates
and add Mangxiao (Mirabilite) while hot. Conclusion: The established content
determination method is accurate and reliable, and the optimized extraction
process for Dachengqi Decoction is stable and feasible.
Key words：Dachengqi Decoction; extraction process optimization; multi-component indicators; AHP-EWM; composite weighting method; central composite design (CCD)-response surface methodology (RSM)
摘要：
目的：优选大承气汤的最佳提取工艺。方法：采用高效液相色谱法测定厚朴酚、和厚朴酚、大黄酸、大黄素、芦荟大黄素、大黄酚、柚皮苷、橙皮苷、新橙皮苷、橙皮素10种成分的含量，以上述成分的含量及出膏率为考察指标，通过层次分析法（AHP）-熵权法（EWM）复合加权确定各指标的权重系数，利用中心组合设计（CCD）-响应面法对大承气汤提取工艺进行优化。结果：方法学考察结果均符合要求，优选出大承气汤的最佳提取工艺为：厚朴、枳实饮片加8倍量水，浸泡30 min，提取1 h，滤液倒入大黄饮片中，浸泡20 min，提取20 min，过滤；厚朴、枳实药渣加6倍量水，提取1 h，滤液倒入大黄药渣中，提取20 min，过滤；合并2次滤液，趁热加入芒硝。结论：建立的含量测定方法准确可靠，优选的大承气汤最佳提取工艺稳定可行。
关键词：大承气汤；提取工艺优化；多指标成分；层次分析法-熵权法；复合加权法；中心组合设计-响应面法
Release time：2025-12-15
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