Analysis of Heavy Metal Pollution in Duzhong (Eucommia Ulmoides) Leaves
Author：KUANG Chuangfu1,2, ZHANG Nian3, LIANG Xuejuan2, GONG Nianchun2, WANG Ailin1, LIU Xiaoli1, PENG Yanmei2
Unit：1.The Second Affiliated Hospital of Hunan University of Chinese Medicine, Changsha Hunan 410005, China; 2.Hunan Academy of Chinese Medicine, Changsha Hunan 410006, China; 3.The First Hospital of Hunan University of Chinese Medicine, Changsha Hunan 410007, China
Quote：引用：匡创富，张年，梁雪娟，龚年春，王艾琳，刘小丽，彭艳梅.杜仲叶中重金属污染分析[J].中医药导报,2025,31(3):89-94.
DOI：10.13862/j.cn43-1446/r.2025.03.015
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Abstract：
Objective: To determine the heavy metal
content in Duzhong (Eucommia ulmoides) leaves from different regions in Hunan
Province and conduct a health risk assessment, providing a reference for the
quality control of Duzhong (Eucommia ulmoides) leaves. Methods: The heavy metal
content in Duzhong (Eucommia ulmoides) leaf samples were measured according to
the 2020 edition of the Pharmacopoeia of the People's Republic of China. Health
risk assessment was performed using the estimated daily intake (EDI), target
hazard quotient (THQ), and carcinogenic risk (CR) models. The relationship
between heavy metals in Duzhong (Eucommia ulmoides) leaves and those in the
soil of their production areas were also investigated. Results: Among 30
batches of Duzhong (Eucommia ulmoides) leaves, the lead content in one batch
did not meet the limit standards specified in the Pharmacopoeia of the People's
Republic of China. The enrichment of cadmium and lead in Duzhong (Eucommia
ulmoides) leaves showed some correlation with the cadmium and lead content in
the soil. The EDI and CR results indicated no significant health risks, while
the THQ results suggested potential health risks in 10 batches of Duzhong
(Eucommia ulmoides) leaves. Conclusion: Duzhong (Eucommia) ulmoides leaves
generally comply with the limit standards, however, certain production areas
exhibit contamination with heavy metals. Targeted heavy metal pollution control
measures should be implemented to ensure the safety of Duzhong (Eucommia
ulmoides) leaves for medicinal use.
Key words：Duzhong (Eucommia ulmoides) leaves; edible and medicinal substance; heavy metals; health risk assessment
摘要：
目的：测定湖南省内不同地区杜仲叶中重金属含量，并对其进行健康风险评估，为杜仲叶的质量控制提供参考。方法：参考2020年版《中华人民共和国药典》方法测定杜仲叶样品中重金属含量，利用每日最大可耐受摄入量（EDI）、靶标危害系数（THQ）和致癌风险（CR）评估模型进行健康风险评估，同时考察杜仲叶中重金属与产地土壤中重金属之间的关系。结果：30批杜仲叶中有1批样品的铅含量不符合《中华人民共和国药典》的限量标准。杜仲叶中镉和铅元素的富集与土壤中镉和铅元素有一定的相关性。EDI和CR的结果未发现明显健康风险，THQ结果显示有10批杜仲叶存在潜在健康风险。结论：杜仲叶基本上符合限量标准，但个别产地杜仲叶重金属存在污染情况，应针对性进行重金属污染治理，以保证杜仲叶的用药安全。
关键词：杜仲叶；食药物质；重金属；健康风险评估
Release time：2025-12-15
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