Research Progress on the Related Mechanisms of Acupuncture in the Treatment of Post-stroke Depression in the Past Decade

Author：WANG Juntao, LV Wenliang, YAN Yan

Unit：Jilin City Hospital of Integrative Chinese and Western Medicine, Jilin Jilin 132000, China

Quote：引用：王俊涛，吕文亮，闫言.近十年针刺治疗卒中后抑郁相关作用机制的研究进展[J].中医药导报,2025,31(3):141-145.

DOI：10.13862/j.cn43-1446/r.2025.03.023

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Abstract：

This paper summarizes the research progress on the mechanisms of acupuncture in the treatment of post-stroke depression (PSD) in the past decade. It is believed that acupuncture has an obvious and definite therapeutic effect on PSD. Its prominent function lies in regulating the content of neurotransmitters in brain tissues. The related mechanisms mainly include regulating the activity of neurotrophic factors, regulating the neuroendocrine system, correcting the inflammatory response, reducing oxidative stress damage, and decreasing the level of serum proteins. It also involves the regulation of the brain-gut axis and the level of homocysteine by acupuncture, so as to achieve the purpose of treating PSD.

Key words：post-stroke depression; acupuncture; mechanism of action; research progress

摘要：本文总结了近十年来针刺治疗卒中后抑郁（PSD）相关作用机制的研究进展，认为针刺治疗PSD效果明显，疗效确切。针刺调节脑组织内神经递质含量的作用突出，相关的作用机制主要为调节神经营养因子活性、调节神经内分泌、纠正炎症反应、减轻氧化应激损伤及减少血清蛋白水平等方面，也包括针刺对脑肠轴及同型半胱氨酸水平的调节，从而达到治疗PSD的目的。

关键词：卒中后抑郁；针刺；作用机制；研究进展

Release time：2025-12-15

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