Research Progress on the Regulation of Exosomal miRNA by Traditional Chinese Medicine in the Treatment of Femoral Head Necrosis

Author：WANG Huachen1, CAO Yuju2, ZHANG Zhihui1, CAO Xingxing1, MIAO Xiyun3, GUO Huiqing1

Unit：1.College of Orthopedics and Traumatology, Henan University of Chinese Medicine, Zhengzhou Henan 450003, China; 2.Zhengzhou Orthopedic Hospital of Traditional Chinese Medicine Affiliated to Henan University of Chinese Medicine, Zhengzhou Henan 450048, China; 3.Henan Provincial Hospital of Traditional Chinese Medicine, Zhengzhou Henan 450002, China

Quote：引用：王华琛，曹玉举，张智辉，曹星星，苗喜云，郭会卿.中药调控外泌体miRNA治疗股骨头坏死研究进展[J].中医药导报,2025,31(5):127-134.

DOI：10.13862/j.cn43-1446/r.2025.05.023

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Abstract：

This paper reviews the research status of exosomal miRNAs in femoral head necrosis, and summarizes the research progress of traditional Chinese medicine in treating femoral head necrosis by regulating exosomal miRNAs. Exosomal miRNAs show great potential in the treatment of femoral head necrosis by promoting osteogenesis, inhibiting osteoclastogenesis, promoting angiogenesis, regulating inflammation, and controlling signaling pathways. Meanwhile, exosomal miRNAs are helpful for the early diagnosis of femoral head necrosis. Traditional Chinese medicine has unique advantages in the treatment of femoral head necrosis, and can exert therapeutic effects by regulating the secretion and function of exosomal miRNAs.

Key words：femoral head necrosis; exosomes; miRNA; Chinese medicine; review

摘要：综述外泌体miRNA在股骨头坏死中的研究现状，总结中医药调控外泌体miRNA治疗股骨头坏死的研究进展。外泌体miRNA通过促进成骨、抑制破骨、促进血管生成、调节炎症及调控信号通路，在股骨头坏死的治疗中显示出巨大的潜力，同时外泌体miRNA有助于股骨头坏死的早期诊断。中医药在股骨头坏死的治疗中具有独特的优势，能够通过调控外泌体miRNA的分泌和功能来发挥治疗作用。

关键词：股骨头坏死；外泌体；miRNA；中药；综述

Release time：2025-12-31

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