Research Progress on the Mechanism of Huangqi (Astragali Radix) and Its Active Ingredients in Anti-Atherosclerosis

Author：SU Zouyu1, TANG Huijie1, WU Haolin2, HUANG Shan1, LIU Huajian1, MENG Qinwen1,3

Unit：1.The First Affiliated Hospital of Hainan Medical University, Haikou Hainan 570100, China; 2.International Research Center for Aging and Tumor, Hainan Medical University, Haikou Hainan 570100, China; 3.College of Traditional Chinese Medicine, Hainan Medical University, Haikou Hainan 570100, China

Quote：引用：苏洲玉，唐慧杰，吴昊霖，黄珊，刘华江，孟庆雯.黄芪及其有效成分抗动脉粥样硬化机制研究进展[J].中医药导报,2025,31(5):135-141.

DOI：10.13862/j.cn43-1446/r.2025.05.024

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Abstract：

Atherosclerosis (AS) is the main pathological basis of cardiovascular and cerebrovascular events, and its pathogenesis is complex and involves a variety of factors.  Huangqi (Astragali Radix) and its active ingredients can exert anti-atherosclerotic effects. The active ingredients in Huangqi (Astragali Radix) such as astragalus polysaccharides, astragaloside IV, flavonoids of astragalus membranaceus, total saponins of astragalus membranaceus, and cycloastragenol in astragalus membranaceus can exert an anti-atherosclerotic effect through mechanisms such as anti-inflammatory response, regulation of lipid metabolism, regulation of programmed cell death, anti-aging, and anti-oxidation.

Key words：atherosclerosis; Huangqi (Astragali Radix); active ingredients; action mechanism; review

摘要：动脉粥样硬化是心脑血管事件的主要病理基础，其发病机制复杂，涉及多种因素。黄芪及其有效成分可以发挥抗动脉粥样硬化作用。黄芪中黄芪多糖、黄芪甲苷、黄芪黄酮类、黄芪总皂苷及环黄芪醇等成分，可以通过抗炎症反应、调节脂质代谢、调节细胞程序性死亡、抗衰老、抗氧化等机制发挥抗动脉粥样硬化作用。

关键词：动脉粥样硬化；黄芪；有效成分；作用机制；综述

Release time：2025-12-31

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