Comparative Research Progress on the Application of Charged Aerosol Detector and Evaporative Light Scattering Detector in Traditional Chinese Medicine Analysis
Author：FU Yu, SUN Yanmin, ZHANG Yulin, WU Yanyan, PANG Qinglin
Unit：Jiangsu Institute for Food and Drug Control, Nanjing Jiangsu 210000, China
Quote：引用：付裕，孙彦敏，张妤琳，吴嫣艳，庞庆林.电喷雾检测器与蒸发光散射检测器在中药分析中应用对比研究进展[J].中医药导报,2025,31(6):146-149,169.
DOI：10.13862/j.cn43-1446/r.2025.06.025
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Abstract：
Traditional Chinese medicine (TCM) exhibits
complex chemical compositions, necessitating diverse analytical methods to
achieve compound purification, separation, and discovery of novel constituents.
As mass-sensitive detectors, both the evaporative light scattering detector
(ELSD) and charged aerosol detector (CAD) are suitable for semi-volatile or
non-volatile compounds, serving as powerful complements to other liquid
chromatography detectors. Although these two detectors have been increasingly
applied in TCM analysis and play significant roles in quality control, notable
differences exist between them in this field. ELSD demonstrates broader
applicability, whereas CAD exhibits superior performance in reproducibility and
sensitivity.
Key words：charged aerosol detector; evaporative light scattering detector; traditional Chinese medicine analysis; quality control; review
摘要：中药成分复杂，为实现化合物的纯化分离及新化合物的发现，分析检测方法需具备多样性。蒸发光散射检测器（ELSD）和电喷雾检测器（CAD）是质量型检测器，均适用于半挥发性或非挥发性物质的检测，可作为其他液相检测器的有力补充。虽然两者在中药分析领域中应用逐步广泛，在中药质量控制中也发挥着重要作用，但在中药分析领域中两者则存在一定的差异性。ELSD的应用更具广泛性，而CAD在重复性、灵敏度等方面更有优势。
关键词：电喷雾检测器；蒸发光散射检测器；中药分析；质量控制；综述
Release time：2026-01-04
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