Discussion on the Etiology and Pathogenesis of Rheumatoid Arthritis from the Perspective of Deficiency, Stasis and Toxin

Author：YE Zifeng1, TANG Xuyi2, KUANG Gaoyan3, KUANG Jianjun2, LU Ming3

Unit：1.Hunan University of Chinese Medicine, Changsha Hunan 410208, China; 2.The Affiliated Hospital of Hunan Academy of Traditional Chinese Medicine, Changsha Hunan 410006, China; 3.The First Hospital of Hunan University of Chinese Medicine, Changsha Hunan 410007, China

Quote：引用：叶子丰，谭旭仪，邝高艳，匡建军，卢敏.从虚、瘀、毒论类风湿关节炎的病因病机[J].中医药导报,2025,31(6):193-196.

DOI：10.13862/j.cn43-1446/r.2025.06.037

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Abstract：Based on the disease characteristics of rheumatoid arthritis (RA), this article discusses the etiology and pathogenesis of RA from the aspects of deficiency, stasis and toxin. Deficiency, stasis and toxin are consistent with the theoretical connotation of RA pathogenesis. Deficiency refers to the insufficiency of vital Qi, manifested as the imbalance of immune regulation, leading to increased susceptibility to RA. Stasis involves blood circulation disorders, which are closely related to inflammation and joint damage in RA. Toxin refers to foreign or endogenous harmful substances, including inflammatory mediators produced by autoimmune reactions, which can aggravate the pathological process of RA.

Key words：rheumatoid arthritis; deficiency; stasis; toxin; etiology and pathogenesis

摘要：

根据类风湿关节炎的疾病特点，从虚、瘀、毒探讨类风湿关节炎（RA）的病因病机。虚、瘀、毒与类风湿关节炎病机理论内涵贴合。虚为正气不足，表现为机体免疫调节失衡，导致RA的易感性增加；瘀涉及血液循环障碍，与RA中的炎症和关节损伤密切相关；毒为外来或内生的有害物质，包括自身免疫反应产生的炎症介质，可加剧RA的病理进程。

关键词：类风湿关节炎；虚；瘀；毒；病因病机

Release time：2026-01-04

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