Analysis of the Treatment of Chronic Fatigue Syndrome by the Spleen-Invigorating and Movement-Promoting Therapy Based on "Spleen-Mitochondria-Inflammation" Theory

Author：LI Rong1, GAO Wei2

Unit：1.Chengdu University of Traditional Chinese Medicine, Chengdu Sichuan 610036, China; 2.Chengdu Traditional Chinese Medicine Hospital of Pidu District, Chengdu Sichuan 611730, China

Quote：引用：李溶，高伟.基于“脾-线粒体-炎症”理论探析健脾助运法治疗慢性疲劳综合征[J].中医药导报,2025,31(6):205-208,212.

DOI：10.13862/j.cn43-1446/r.2025.06.040

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Abstract：

The spleen governs transportation and transformation, serving as the source of Qi and blood biochemistry to nourish all parts of the body. Mitochondria, known as the "energy factories," share a close relationship with the spleen. Mitochondrial dysfunction promotes the escalation of inflammatory responses in the body, forming a "spleen-mitochondria-inflammation" axis that guides pathological changes in chronic fatigue syndrome (CFS). From the perspectives of molecular cytology and immunology, this paper integrates traditional Chinese medicine and cell science based on the "spleen-mitochondria-inflammation" theory to analyze the pathogenesis of CFS. It also explores the feasibility of treating CFS with spleen-invigorating and movement-promoting therapy, aiming to deepen the understanding of CFS's immunological pathogenesis and provide insights for its clinical management.

Key words：chronic fatigue syndrome; spleen governing transportation and transformation; mitochondria; inflammation; integration of traditional Chinese and western medicine

摘要：

脾主运化且为气血生化之源，濡养四肢百骸。线粒体作为“能量工厂”与脾之间存在着紧密的联系。而线粒体功能障碍会促使炎症反应在体内扩张。这就形成了“脾-线粒体-炎症”三者间的关系轴，在慢性疲劳综合征（CFS）中引导着病理变化。从分子细胞学及免疫学角度出发，基于“脾-线粒体-炎症”理论，将传统中医学与细胞科学相结合以探析CFS的病机，分析健脾助运疗法治疗CFS的可行性，有助于理解CFS的免疫学病机，以期为CFS治疗提供建议。

关键词：慢性疲劳综合征；脾主运化；线粒体；炎症；中西医结合

Release time：2026-01-04

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