Discussion on the Acupuncture Treatment for Alzheimer's Disease Based on the Theory of "Kidney Deficiency and Toxin Damage" and Neuroinflammation
Author：YU Zhaoxie1,2, SHEN Feng1,2, WANG Yao2,3, LI Yanan1,2, SUN Guojie1, WANG Yanchun2,4
Unit：1.College of Acupuncture-Moxibustion and Orthopaedics, Hubei University of Chinese Medicine, Wuhan Hubei 430065, China; 2.Hubei Shizhen Laboratory, Wuhan Hubei 430061, China; 3.College of Physical Education and Health, Hubei University of Chinese Medicine, Wuhan Hubei 430065, China; 4.College of Chinese Medicine, Hubei University of Chinese Medicine, Wuhan Hubei 430065, China
Quote：引用：於赵勰，沈峰，汪瑶，李亚楠，孙国杰，王彦春.基于“肾虚毒损”理论及神经炎症探讨针灸治疗阿尔茨海默病[J].中医药导报,2025,31(7):138-143.
DOI：10.13862/j.cn43-1446/r.2025.07.024
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Abstract：
The
incidence of Alzheimer's disease (AD) is rising annually, placing a heavy
burden on both society and families. Based on the theory of "kidney
deficiency and toxic damage," this paper posits that the core pathogenesis
of AD lies in kidney essence deficiency as the root cause, and the accumulation
of phlegm, fluid, and blood stasis forming toxins as the manifestation. These
two factors interact and drive the onset and progression of AD.
Neuroinflammation is a key pathological mechanism of AD, characterized by Aβ
protein deposition, Tau protein hyperphosphorylation, and abnormal activation
of glial cells, which trigger chronic inflammatory responses and exacerbate
neuronal damage. Integrating the theory of "kidney deficiency and toxic
damage" with modern AD pathological mechanisms, this paper explores the
potential mechanism of acupuncture in AD intervention. It proposes the use of
Baihui (DU20), Taixi (KI3), Shenshu (BL23), and Zusanli (ST36) as primary
acupoints to exert a synergistic effect of "nourishing the kidney,
regulating the Du meridian, harmonizing Qi and blood, and opening the orifices
to awaken the mind." By regulating neuroinflammatory responses and
significantly reducing the release of inflammatory factors, this approach aims
to improve cognitive function, providing a more comprehensive scientific basis
for the prevention and treatment of AD with acupuncture.
Key words：Alzheimer's disease; neuroinflammation; kidney deficiency and toxic damage; acupuncture
摘要：
阿尔茨海默病（AD）发病率呈逐年上升态势，给社会和家庭带来了沉重负担。基于“肾虚毒损”理论，本文认为AD的核心病机为以肾精亏虚为本，痰饮瘀血胶结成毒为标，两者相互作用，共同推动AD的发生与发展。神经炎症是AD重要的病理机制，主要表现为Aβ蛋白沉积、Tau蛋白异常磷酸化以及神经胶质细胞的异常激活，从而促发慢性炎症反应，加重神经损伤。结合“肾虚毒损”理论与现代AD病理机制，本文深入探讨针灸在干预AD中的潜在作用机制，提出以百会、太溪、肾俞、足三里为主穴，发挥“益肾调督、和畅气血、开窍醒神”的协同作用，调控神经炎症反应，明显减少炎症因子释放，改善认知功能，旨在为针灸防治AD提供更为全面的科学依据。
关键词：阿尔茨海默病；神经炎症；肾虚毒损；针灸
Release time：2026-01-06
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