Discussion on the Connotation of "Opening Xuanfu" Method in the Treatment of Stroke from the Perspective of Transient Receptor Potential Channels in the Blood-Brain Barrier
Author：LI Jiawang1, YANG Zhen1, ZHANG Hongrui2,3, CHEN Xiangyun1, CHEN Danni1, DING Wei1, LIU Zhenhong2,3
Unit：1.School of Chinese Medicine, Beijing University of Chinese Medicine, Beijing 102401, China; 2.Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China; 3.Institute for Brain Disorders, Beijing University of Chinese Medicine, Beijing 100700, China
Quote：引用：李家旺，杨桢，张鸿瑞，陈香云，陈丹妮，丁薇，刘珍洪.从血脑屏障瞬时受体电位通道探讨“开通玄府”法治疗中风病内涵[J].中医药导报,2025,31(7):223-227.
DOI：10.13862/j.cn43-1446/r.2025.07.038
PDF：
Download PDF
Abstract：
The
blood-brain barrier and cerebral Xuanfu share identity. The occlusion of
cerebral Xuanfu is a key factor leading to the occurrence and development of
ischemic stroke. The traditional Chinese medicine (TCM) approach of
"opening Xuanfu" has demonstrated significant efficacy in treating
ischemic stroke. There is a close connection between transient recepter
potential (TRP) ion channels in the blood-brain barrier and cerebral Xuanfu,
which exert physiological effects in regulating brain function through the
blood-brain barrier. This is similar to the mechanism of the TCM "opening
Xuanfu" method, that is, playing roles in protecting the barrier and
facilitating material exchange. This paper reveals the molecular mechanism of
"opening Xuanfu" method, emphasizes the therapeutic significance of
using acrid-flavored herbs and wind herbs for ischemic stroke, and provides
effective guidance for clinical treatment of ischemic stroke using TRP
channels.
Key words：ischemic stroke; opening Xuanfu therapy; cerebral Xuanfu; transient receptor potential ion channel; blood-brain barrier; traditional Chinese medicine
摘要：血脑屏障和脑玄府具备同一性，脑玄府闭塞是导致缺血性中风发生和发展的关键因素，中医“开通玄府”法治疗缺血性中风疗效显著。血脑屏障瞬时受体电位（TRP）离子通道与脑玄府之间存在密切联系，通过血脑屏障发挥调控脑功能的生理作用，这与中医“开通玄府”法的机制相似，即发挥保护屏障、物质交换等作用。揭示“开通玄府”法的分子机制，强调使用辛味药、风药等对缺血性中风的治疗意义，为临床使用TRP通道治疗缺血性中风提供有效指导。
关键词：缺血性中风；开通玄府法；脑玄府；瞬时受体电位离子通道；血脑屏障；中医药
Release time：2026-01-06
click-through rate：157