Research Progress in the Diagnosis and Treatment of Cancer-Related Fatigue: Perspectives from Traditional Chinese and Western Medicine
Author：QIN Huanhuan1, WANG Jiangbao1, QU Jianmin1, ZHANG Yang2, LI Caixia2, WANG Gang2
Unit：1.Shaanxi University of Chinese Medicine, Xianyang Shaanxi 712046, China; 2.The Second Affiliated Hospital of Shaanxi University of Chinese Medicine, Xianyang Shaanxi 712000, China
Quote：引用：秦欢欢，王江保，屈建敏，张杨，李彩霞，王刚.诊治癌因性疲乏的中西医研究进展[J].中医药导报,2025,31(9):131-138.
DOI：10.13862/j.cn43-1446/r.2025.09.023
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Abstract：
This article aims to summarize and analyze
the literature on the etiology, pathogenesis, and treatment of cancer-related
fatigue (CRF) from both Traditional Chinese Medicine (TCM) and Western medicine
perspectives, providing references for clinical research. CRF is a common
complication in cancer patients, related to the tumor itself, treatment
modalities, emotional and cognitive factors, among others. Mechanisms such as
inflammatory cytokine dysregulation, mitochondrial and muscle dysfunction, and
genetic polymorphisms are associated with the development and progression of
CRF. Scales like PFS-R and FACT-F are essential for diagnosing and assessing
CRF. Treatment primarily involves non-pharmacological interventions,
supplemented by pharmacological therapy. In TCM, CRF falls under the category
of "consumptive disease" (Xu Lao). Its nature is characterized by
root deficiency (ben xu) and surface excess (biao shi), primarily identified as
deficiency of qi, blood, yin, and yang as the root cause, with stasis, toxin,
phlegm, and dampness as the manifesting symptoms. It is classified into
different syndrome patterns and treated with internal therapies, external
therapies, and lifestyle regulations.
Key words：cancer-related fatigue (CRF); malignant tumor; consumptive disease (Xu Lao); traditional Chinese and Western medicine; review
摘要：总结分析癌因性疲乏（CRF）的病因病机、发病机制、治疗方法方面的中西医文献，为临床研究提供借鉴。CRF是肿瘤患者常见的并发症，其病因与肿瘤自身、治疗方法、情绪认知等均有关。炎症因子失调、线粒体及肌肉功能失调、基因多态性等多种机制都与CRF发生发展相关联。Piper疲乏修订量表（PFS-R）、癌症治疗功能评估疲乏量表（FACT-F）等是诊断、评估CRF的重要依据，治疗时以非药物干预为主，辅之药物疗法。CRF属中医“虚劳”范畴，病性本虚标实，辨以气血阴阳亏虚为本，瘀、毒、痰、湿为标，将其分为不同证型加以介绍，并运用内治法、外治法及调护养生等措施。
关键词：癌因性疲乏；恶性肿瘤；虚劳；中西医；综述
Release time：2026-01-08
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