Research Progress on the Use of Blood Activating and Blood Stasis Removing Traditional Chinese Medicines to Regulate Bone Metabolism in the Treatment of Hormonal Osteonecrosis of the Femoral Head

Author：WANG Kai1, LI Huiying2, MENG Dongfang2, LEI Yang1

Unit：1.The First Clinical School of He'nan University of Traditional Chinese Medicine, Zhengzhou He'nan 450003, China; 2.The First Affiliated Hospital of He'nan University of Traditional Chinese Medicine, Zhengzhou He'nan 450000, China

Quote：引用：王凯，李慧英，孟东方，雷阳.活血化瘀类中药调节骨代谢治疗激素性股骨头坏死的研究进展[J].中医药导报,2025,31(10):84-88,165.

DOI：10.13862/j.cn43-1446/r.2025.10.015

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Abstract：

Through literature reading and compilation, this article describes the research progress on the use of blood activating and blood stasis removing traditional Chinese medicines to regulate bone metabolism in the treatment of hormonal osteonecrosis of the femoral head. The pathogenesis of femoral head necrosis in traditional Chinese medicine is related to the body feeling evil energy, weak kidney essence that has been retained in the body for a long time, poor circulation of qi and blood, blood stasis that blocks the bone collaterals, and damages bone collaterals, and insufficient bone marrow. Bone metabolism is the process of generation, repair and reconstruction of bone marrow and bone cells. If stimulated by glucocorticoids, alcohol and other factors, it can easily lead to abnormal bone metabolism, and osteocyte apoptosis can lead to femoral head necrosis. The blood activating and blood stasis removing traditional Chinese medicines, such as Sanqi (panax notoginseng), Gucuibu (drynariae), Huzhang (polygonum cuspidatum), Hongjingtian (rhodiola rosea), Danshen (salvia miltiorrhiza), Jianghuang (curcuma longa), Chuanxiong (ligusticum chuanxiong), Honghua (safflower), Jixueteng (spatholobus suberectus), Ercha (catechu), Xuejie (DaemonoropsdracoBl.), Ruxiang (frankincense), Taoren (peach kernel), Tubiechong (woodworm), Zirantong (natural copper), Banmao (mylabris phalerata pallas), and Shuizhi (leeches), and Chinese medicine compound such as Taohong Siwu Tang (桃红四物汤), Bushen Huoxue Decoction (补肾活血汤), Jianpi Bushen Prescription (健脾补肾方) can regulate bone metabolism levels through several signal pathways to treat femoral head necrosis .

Key words：hormonal osteonecrosis of the femoral head; blood activating and blood stasis; bone metabolism; review

摘要：通过文献阅读与整理，阐述活血化瘀类中药调节骨代谢治疗激素性股骨头坏死的研究进展。股骨头坏死中医病机与人体感受邪气，留滞体内，久之肾精虚弱，气血运行不畅，瘀血内阻骨络，骨络受损、骨髓虚少有关。骨代谢是骨髓及骨细胞的生成、修复重建的过程，如受到糖皮质激素、酒精等因素刺激易造成骨代谢异常，骨细胞凋亡引发股骨头坏死。活血化瘀类中药如三七、骨碎补、虎杖、红景天、丹参、姜黄、川芎、红花、鸡血藤、儿茶、血竭、乳香、桃仁、土鳖虫、自然铜、斑螯、水蛭等，中药复方如桃红四物汤、补肾活血汤、健脾补肾方等，可通过多条信号通路调节骨代谢水平发挥治疗股骨头坏死作用。

关键词：激素性股骨头坏死；活血化瘀；骨代谢；综述

Release time：2026-01-08

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