Clinical Study on the Efficacy of Bushen Jiangzhuo Decoction (补肾降浊方) for Diabetic Kidney Disease Complicated with Hyperuricemia in the Xiangxi Ethnic Region

Author：LI Ping1, OU Yuanyuan2, LONG Zixiao2

Unit：1.The Second Affiliated Hospital of Hunan University of Chinese Medicine, Changsha Hunan 410005, China; 2.Fenghuang County Traditional Chinese Medicine Hospital, Xiangxi Tujia and Miao Autonomous Prefecture Hunan 416200, China

Quote：引用：李萍，欧媛媛，龙姿晓.补肾降浊方治疗湘西民族地区糖尿病肾脏病合并高尿酸血症的临床研究[J].中医药导报,2026,32(2):113-116.

DOI：10.13862/j.cn43-1446/r.2026.02.018

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Abstract：

Objective: To observe the clinical efficacy of Bushen Jiangzhuo Decoction (补肾降浊方) in treating patients with diabetic kidney disease (DKD) complicated by hyperuricemia (HUA) in the Xiangxi ethnic region. Methods: Seventy-four DKD-HUA patients were randomly divided into a control group and a treatment group, with 37 cases in each group. The control group received dapagliflozin and febuxostat, while the treatment group received Bushen Jiangzhuo Decoction in addition to the control group's treatment for 12 weeks. Serum uric acid (SUA), serum creatinine (Scr), blood urea nitrogen (BUN), estimated glomerular filtration rate (eGFR), 24-hour urinary protein, TCM syndrome scores, and adverse reactions were compared between the two groups, and clinical efficacy was evaluated. Results: The total effective rate was 94.59% (35/37) in the treatment group, significantly higher than 67.57% (25/37) in the control group (P<0.01). After treatment, SUA, Scr, BUN, and 24-hour urinary protein levels decreased, while eGFR increased in both groups  (P<0.01). All improvements were significantly greater in the treatment group than in the control group  (P<0.01). TCM syndrome scores also decreased more markedly in the treatment group (P<0.01). No significant difference in the incidence of adverse reactions was observed between the two groups (P>0.05). Conclusion: Bushen Jiangzhuo Decoction shows favorable clinical efficacy in treating DKD-HUA patients in the Xiangxi ethnic region.

Key words：diabetic kidney disease; hyperuricemia; Bushen Jiangzhuo Decoction; integrated traditional Chinese and Western medicine therapy; Xiangxi ethnic region

摘要：

目的：观察补肾降浊方治疗湘西民族地区糖尿病肾脏病（DKD）合并高尿酸血症（HUA）的临床疗效。方法：将74例DKD合并HUA患者随机分为对照组与治疗组，每组37例。对照组患者予达格列净片及非布司他治疗，治疗组患者在对照组基础上予补肾降浊方治疗，疗程均为12周。比较两组患者血尿酸（SUA）、血肌酐（Scr）、血尿素氮（BUN）、肾小球滤过率（GFR）、24 h尿蛋白定量、中医证候积分及不良反应，并评价临床疗效。结果：总有效率治疗组为94.59%（35/37），对照组为67.57%（25/37），治疗组高于对照组（P<0.01）。治疗后，两组患者SUA、Scr、BUN、24 h尿蛋白定量水平均低于治疗前，GFR均高于治疗前，差异均有统计学意义（P<0.01）；且治疗组患者SUA、Scr、BUN、24 h尿蛋白定量水平低于对照组，GFR高于对照组，差异均有统计学意义（P<0.01）。治疗后，两组患者中医证候积分均低于治疗前，差异均有统计学意义（P<0.01）；且治疗组患者中医证候积分低于对照组，差异有统计学意义（P<0.01）。两组患者不良反应发生率比较，差异无统计学意义（P<0.05）。结论：补肾降浊方治疗湘西民族地区DKD合并HUA患者有较好临床疗效。

关键词：糖尿病肾脏病；高尿酸血症；补肾降浊方；中西医结合疗法；湘西民族地区

Release time：2026-03-05

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