Research Progress of Chinese Medicine in Regulating PINK1/Parkin Pathway for the Prevention and Treatment of Alzheimer's Disease

Author：YAN Xinyu1, SUN Xinghua2, ZHANG Miao2, 3

Unit：1.Heilongjiang University of Chinese Medicine, Harbin Heilongjiang 150040, China; 2.The Second Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin Heilongjiang 150001, China; 3.Heilongjiang Provincial Key Laboratory of Acupuncture-Medicine Integrated Therapy for Major Cerebral Diseases, Harbin Heilongjiang 150040, China

Quote：引用：颜新宇，孙兴华，张淼.中药调控PINK1/Parkin通路防治阿尔茨海默病的研究进展[J].中医药导报,2026,32(2):173-178.

DOI：10.13862/j.cn43-1446/r.2026.02.029

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Abstract：

Abnormal mitophagy function is one of the major pathogenesis of Alzheimer's disease (AD). As the main signal transduction pathway of mitophagy, the PTEN-induced kinase 1 (PINK1)/Parkin pathway plays a crucial role in mitochondrial quality control and maintenance of mitochondrial homeostasis. In recent years, studies have found that Chinese medicine monomers such as tenuifolin and β-asarone, as well as Chinese medicine compound prescriptions such as Huangqi Powder (黄芪散) and Kaixin Powder (开心散), can prevent and treat AD by intervening in mitophagy mediated by the PINK1/Parkin pathway.

Key words：Alzheimer's disease; PINK1/Parkin pathway; Chinese medicine; mitophagy; Chinese medicine monomer

摘要：线粒体自噬功能异常是阿尔茨海默病（AD）的主要发病机制之一，而PTEN诱导激酶1（PINK1）/帕金蛋白（Parkin）通路作为线粒体自噬的主要信号转导通路，在线粒体质量控制以及维持线粒体稳态中发挥至关重要的作用。近年来，研究发现细叶远志皂苷、β细辛醚等中药单体和黄芪散、开心散等中药复方均可通过干预PINK1/Parkin通路介导的线粒体自噬来防治AD。

关键词：阿尔茨海默病；PINK1/Parkin通路；中药；线粒体自噬；中药单体

Release time：2026-03-05

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