Research Progress on the Regulation of Relevant Signaling Pathways by Traditional Chinese Medicine in the Treatment of Parkinson's Disease

Author：AN Yi1,2, LIU Tong1,2, SUN Hehao3, ZHAO Duo1,2, LIU Fugui1,2

Unit：1.The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou Henan 450000, China; 2.The First Clinical Medical College of Henan University of Chinese Medicine, Zhengzhou Henan 450000, China; 3.Graduate School of Chinese People's Liberation Army General Hospital, Beijing 100853, China

Quote：引用：安怡，刘潼，孙和昊，赵铎，刘福贵.中医药调控相关信号通路治疗帕金森病研究进展[J].中医药导报,2026,32(3):123-131.

DOI：10.13862/j.cn43-1446/r.2026.03.020

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Abstract：

Parkinson's disease (PD) is a common neurodegenerative disease in the elderly. Traditional Chinese medicine (TCM) has shown significant therapeutic effects on both motor and non-motor symptoms of PD. This paper summarizes recent studies on how TCM monomers, extracts, and formulas intervene in PD by regulating signaling pathways such as the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt)/mammalian target of rapamycin (mTOR) pathway, the Toll-like receptor 4 (TLR4)/myeloid differentiation factor 88 (MyD88)/nuclear factor-kappa B (NF-κB) pathway, the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway, the secreted glycoprotein (Wnt)/β-catenin pathway, the mitogen-activated protein kinase (MAPK) pathway, and the activation of the NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasome. These actions delay the pathological progression of PD and improve its clinical symptoms, demonstrating the unique advantages of TCM in treating PD and providing direction for future basic and clinical research on TCM intervention in Parkinson's disease.

Key words：Parkinson's disease; signaling pathway; traditional Chinese medicine monomer; Chinese herbal extract; traditional Chinese medicine formula; review

摘要：

帕金森病（PD）是老年人常见的神经退行性疾病，中医药治疗PD运动症状与非运动症状具有显著疗效。通过总结近年来中药单体、提取物及复方调控磷脂酰肌醇3－激酶（PI3K）/蛋白激酶B（Akt）/哺乳动物雷帕霉素靶蛋白（mTOR）、Toll受体4（TLR4）/髓系分化因子88（MyD88）/核因子κB（NF-κB）、核转录因子红系2相关因子2（Nrf2）、分泌型糖蛋白（Wnt）/β-连环蛋白（β－catenin）、丝裂原活化蛋白激酶（MAPK）及NOD样受体热蛋白结构域相关蛋白3（NLRP3）炎性小体等信号通路延缓PD病理进展与改善PD临床症状的相关研究，以展现中医药治疗PD的独特优势，为未来中医药干预帕金森病的基础研究与临床研究提供导向。

关键词：帕金森病；信号通路；中药单体；中药提取物；中药复方；综述

Release time：2026-04-22

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