Application of Cinnamaldehyde in Methicillin-Resistant Staphylococcus Aureus Pneumonia in Mice

Author：GUO Xiaoru, WANG Jia, GAO Yue, WANG Xiaolu, DENG Jiehua

Unit：The Second Hospital of Hebei Medical University, Shijiazhuang Hebe 050000, China

Quote：引用：郭晓如，王佳，高越，王晓路，邓洁华.肉桂醛在小鼠耐甲氧西林金黄色葡萄球菌肺炎中的应用研究[J].中医药导报,2026,32(4):36-40.

DOI：10.13862/j.cn43-1446/r.2026.04.007

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Abstract：

Objective: To evaluate the efficacy and antibacterial action of cinnamaldehyde in the treatment of methicillin-resistant Staphylococcus aureus pneumonia in immunosuppressed mice. Methods: Totally 180 immunosuppressed mice with methicillin-resistant Staphylococcus aureus pneumonia were randomly divided into cinnamaldehyde [240, 120, 60 mg/(kg·d)]  treatment groups, a Linezolid positive control group, a negative control treated with Tween saline, and a model group. Except for the model group, which was not treated with drugs, the other groups were treated with drugs by gavage 14 days continuously, and the lung tissue samples of mice in each group were collected for blood agar bacterial culture, histopathological section (HE staining), and electron microscopy examination 24 hours after the last drug administration. Results: The bacterial clearance rate was 86.67% (26/30) and the pathological inflammatory cell clearance rate was 76.67% (23/30) in the cinnamaldehyde [240 mg/（kg·d）] treatment group, which was higher than that of the Linezolid positive control group [70.00% (21/30) and 63.33% (19/30) respectively]. Transmission electron microscopy showed that cinnamaldehyde [240 mg/(kg·d)] destroyed the cell wall of methicillin-resistant Staphylococcus aure, and that the organelles were dissolved and disappeared, resulting in cell death. Conclusion: Cinnamaldehyde [(240 mg/(kg·d)] treatment of methicillin-resistant Staphylococcus aureus pneumonia in immunosuppressed mice has significant efficacy and strong antibacterial activity, and it is superior to linezolid.

Key words：Cinnamaldehyde; methicillin-resistant Staphylococcus aureus; pneumonia; transmission electron microscope; mouse

摘要：

目的：评估肉桂醛治疗免疫抑制小鼠耐甲氧西林金黄色葡萄球菌肺炎的疗效和抗菌作用。方法：将180只免疫抑制耐甲氧西林金黄色葡萄球菌肺炎小鼠随机分为肉桂醛[240、120、60 mg/（kg·d）]治疗组、利奈唑胺阳性对照组、吐温盐水阴性对照组和模型组。除了模型组不给药外，其余组均连续灌胃给药14 d，停药24 h后采集各组小鼠肺组织标本进行血平板细菌培养、组织病理切片（HE染色）和透射电子显微镜检查。结果：肉桂醛[（240 mg/（kg·d）]治疗组细菌清除率达到86.67%（26/30）、病理的炎症细胞清除率达到76.67%（23/30），高于利奈唑胺阳性对照组的细菌清除率70.00%（21/30）及病理的炎症细胞清除率63.33%（19/30）；透射电子显微镜下观察到肉桂醛[240 mg/（kg·d）]可破坏耐甲氧西林金黄色葡萄球菌细胞壁，使细胞器溶解消失，导致细胞死亡。结论：肉桂醛[240 mg/（kg·d）]治疗免疫抑制小鼠耐甲氧西林金黄色葡萄球菌肺炎具有显著疗效及较强的抗菌作用，且优于利奈唑胺。

关键词：肉桂醛；耐甲氧西林金黄色葡萄球菌；肺炎；透射电子显微镜；小鼠

Release time：2026-04-26

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