Research Progress on the Hepatoprotective Effects and Mechanisms of Gallic Acid from the Extract of Wubeizi (Galla Chinensis)

Author：ZHU Jiling, YANG Fan

Unit：Renmin Hospital of Wuhan University, Wuhan Hubei 430060, China

Quote：引用：朱纪玲，杨凡.五倍子提取物没食子酸的肝脏保护作用及机制研究进展[J].中医药导报,2026,32(4):129-135.

DOI：10.13862/j.cn43-1446/r.2026.04.021

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Abstract：

Wubeizi (Galla Chinensis) contains tannins, gallic acid, and other components. Gallic acid is a natural polyphenolic compound. It exhibits significant hepatoprotective effects, alleviating various types of liver injury, regulating hepatic metabolic processes, and inhibiting liver fibrosis. Its molecular mechanisms involve multiple aspects, including antioxidation, anti-inflammation, apoptosis regulation, and signal pathway modulation.

Key words：Wubeizi (Galla Chinensis); gallic acid; hepatoprotective effect; liver disease; review

摘要：五倍子中含有鞣质、没食子酸等成分，其中没食子酸是一种天然多酚类化合物。没食子酸具有显著的保肝作用，能够改善肝脏损伤、调节肝脏代谢、抑制肝纤维化。其分子机制涉及抗氧化、抗炎、凋亡、调节信号通路等多个方面。

关键词：五倍子；没食子酸；保肝作用；肝脏疾病；综述

Release time：2026-04-26

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