Discussion on the Relationship between Ulcerative Colitis and Intestinal Flora and the Cold and Heat Properties of Fecal Bacteria Based on the Disease Characteristics of Traditional Chinese Medicine
Author：WEN Na1,2,3,4, HUANG Chaoqun1,2,3,4, HU Yunlian1,2,3,4
Unit：1.Hubei Provincial Hospital of Traditional Chinese Medicine, Wuhan Hubei 430000, China; 2.Hubei Key Laboratory of Liver and Kidney Research and Application of Traditional Chinese Medicine, Wuhan Hubei 430000, China; 3.Hubei Sizhen Laboratory, Wuhan Hubei 430000, China; 4.Affiliated Hospital of Hubei University of Chinese Medicine, Wuhan Hubei 430000, China
Quote：引用：文娜，黄超群，胡运莲.基于中医病性探讨溃疡性结肠炎与肠道菌群关系以及粪菌寒热属性[J].中医药导报,2025,31(1):153-157,168.
DOI：10.13862/j.cn43-1446/r.2025.01.027
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Abstract：
Ulcerative colitis is a kind of inflammatory bowel disease, which has the characteristics of repeated attacks, poor efficacy, and increasing incidence year by year. The incidence of ulcerative colitis may be related to intestinal microecological disorders. In clinical practice, fecal microbiota transplantation has been attempted, which involves transplanting the gut microbiota from healthy human feces to patients, reshaping their gut microbiota, and achieving the goal of treating intestinal and extraintestinal diseases related to microbiota imbalance. However, the current sample is small and the curative effect is mixed. The traditional Chinese medical (TCM) believes that intestinal flora is closely related to TCM syndrome types, and different TCM syndrome types belong to different diseases and are related to different causes, and intestinal flora may be the microscopic manifestation of etiological diseases. From the perspective of Chinese medicine, this paper analyzes the changes of intestinal flora under different etiology, disease and syndrome types of ulcerative colitis, making the etiologies and pathologies from abstract to concrete. In addition, through the use of efficacy and source analysis methods, explore the cold and heat properties of fecal microbiota transplantation fluid, and provide ideas for the study of the pathogenesis of ulcerative colitis and the use of fecal microbiota transplantation for syndrome differentiation in TCM.
Key words：ulcerative colitis; gut microbiota; fecal microbiotatransplantation; etiology; nature of disease; cold-heat attribute
摘要：
溃疡性结肠炎是炎症性肠病的一种，具有反复发作、疗效欠佳及发病率逐年升高的特点。溃疡性结肠炎的发病，可能与肠道微生态失调有关，临床上尝试使用粪菌移植的方式，即将健康人粪便中肠道菌群移植给患者，重塑患者肠道菌群，从而实现治疗菌群失调相关的肠内及肠外疾病的目的。但目前样本较小，疗效不一。中医认为肠道菌群与中医证型关系密切，不同的中医证型属于不同的病性，与不同的病因相关。肠道菌群可能是病因病性的微观体现。从中医角度，分析溃疡性结肠炎的不同病因、病性、证型下肠道菌群的变化，使病因、病性由抽象化到具体化，并通过以效验性法、审本求源法探究粪菌移植液的寒热属性，为中医研究溃疡性结肠炎发病机制和辨证使用粪菌移植提供思路。
关键词：溃疡性结肠炎；肠道菌群；粪菌移植；病因；病性；寒热属性
Release time：2025-12-01
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