Exploring the Regulatory Mechanism of Macrophage Glucose Metabolism Reprogramming in Asthma Based on the Theory of "Qi Deficiency and Pathogen Retention"

Author：YU Huan1, SHUAI Yunfei1, GUO Wenyuan2, CAI Meng3, WANG Mengqing1

Unit：1.The First Clinical College of Hunan University of Chinese Medicine, Changsha Hunan 410007, China; 2.College of Acupuncture and Orthopedics, Hubei University of Chinese Medicine, Wuhan Hubei 430061, China; 3.Zhujiang Hospital, Southern Medical University, Guangzhou Guangdong 510280, China

Quote：引用：余欢，帅云飞，郭文媛，蔡萌，王孟清.基于“虚气留滞”探讨巨噬细胞糖代谢重编程在哮喘中的调控机制[J].中医药导报,2025,31(10):125-130.

DOI：10.13862/j.cn43-1446/r.2025.10.022

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Abstract：

The onset of asthma is primarily rooted in Yang Qi deficiency of the Lung, Spleen, and Kidney, accompanied by the accumulation of turbid pathogens and the latent presence of phlegm and blood stasis. The combination of internal and external pathogens leads to the recurrent nature of this disease, which aligns with the theory of "Qi Deficiency and Pathogen Retention". Macrophages, part of the innate immune system, can polarize into different phenotypes in response to microenvironmental changes, thereby regulating the body's immune balance and influencing the occurrence and development of asthma. Glucose metabolism reprogramming is a crucial factor affecting macrophage polarization. Yang Qi deficiency is a key prerequisite for glucose metabolism reprogramming, while latent phlegm and blood stasis are driving factors. Changes in the internal microenvironment can also lead to shifts in the body's energy metabolism mode.

Key words：bronchial asthma; qi deficiency and pathogen retention; macrophage polarization; glucose metabolism reprogramming

摘要：哮喘发病以肺脾肾三脏阳气虚损为先，浊邪积滞、痰瘀伏藏为助，内外合邪导致本病反复发作，与“虚气留滞”理论不谋而合。巨噬细胞是先天免疫系统的一部分，可根据微环境变化极化为不同表型，从而调控机体免疫平衡影响哮喘的发生发展。糖代谢重编程是影响其极化的重要因素，阳气亏虚是糖代谢重编程的重要前提。痰瘀伏藏是糖代谢重编程的推动要素，体内微环境的变化亦可导致机体能量代谢模式的转变。

关键词：支气管哮喘；虚气留滞；巨噬细胞极化；糖代谢重编程

Release time：2026-01-08

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