Effects of Kongxuan Zhitong Decoction (控眩止痛汤) Combined with Repetitive Transcranial Magnetic Stimulation on Clinical Symptoms and Cerebral Blood Flow in Patients with Vestibular Migraine

Author：ZHANG Min, WANG Ruixue, WANG Jiangqiao, YANG Li, WANG Changyin

Unit：Handan Hospital of Traditional Chinese Medicine, Handan Hebei 056001, China

Quote：引用：张敏，王瑞雪，王江乔，杨丽，王长垠.控眩止痛汤联合重复经颅磁刺激对前庭性偏头痛患者临床症状及脑血流的影响[J].中医药导报,2026,32(2):109-112,134.

DOI：10.13862/j.cn43-1446/r.2026.02.017

PDF： Download PDF

Abstract：

Objective: To investigate the effects of Kongxuan Zhitong Decoction (控眩止痛汤) combined with repetitive transcranial magnetic stimulation (rTMS) on clinical symptoms and cerebral blood flow in patients with vestibular migraine (VM). Methods: Eighty-two VM patients with phlegm-heat stagnation syndrome were randomly divided into a flunarizine group and a combination group using a random number table, with 41 cases in each group. The flunarizine group was treated with flunarizine hydrochloride capsules, while the combination group received Kongxuan Zhitong Decoction combined with rTMS. TCM syndrome scores, cerebral blood flow velocity, headache scores (VAS), Dizziness Handicap Inventory (DHI) scores, and levels of related cytokines were observed before and after treatment in both groups, and clinical efficacy was evaluated. Results: After treatment, TCM syndrome scores, blood flow velocities in the left/right vertebral artery (L/RVA) and basilar artery (BA), VAS scores, DHI scores, and levels of calcitonin gene-related peptide (CGRP), serum lysophosphatidic acid (LPA), and endothelin-1 (ET-1) were significantly reduced in both groups (P<0.05). These indicators in the combination group were significantly lower than those in the flunarizine group (P<0.05). The total effective rate in the combination group was 95.12% (39/41), significantly higher than the 78.05% (32/41) in the flunarizine group (P<0.05). Conclusion: Kongxuan Zhitong Decoction combined with rTMS can alleviate clinical symptoms, reduce cerebral blood flow velocity, and improve cerebral ischemia in patients with VM.

Key words：vestibular migraine; Kongxuan Zhitong Decoction; repetitive transcranial magnetic stimulation; cerebral blood flow velocity

摘要：目的：探讨控眩止痛汤联合重复经颅磁刺激（rTMS）对前庭性偏头痛（VM）患者临床症状及脑血流的影响。方法：纳入82例痰热郁阻型VM患者为研究对象，采用随机数字表法将患者分为氟桂利嗪组和联合组，各41例。氟桂利嗪组给予盐酸氟桂利嗪胶囊治疗，联合组给予控眩止痛汤与rTMS联合治疗。观察两组患者治疗前和治疗后中医证候积分、脑血流速度、头痛评分、眩晕障碍量表（DHI）评分及相关细胞因子水平，并评估两组患者的临床疗效。结果：治疗后两组患者中医证候积分、左/右侧大脑椎动脉（L/RVA）和基底动脉（BA）水平、视觉模拟评分表（VAS）、DHI评分、降钙素原基因相关肽（CGRP）、血清溶血磷脂酸（LPA）及内皮素-1（ET-1）水平均降低（P＜0.05），且联合组上述指标显著低于氟桂利嗪组（P＜0.05）；联合组患者治疗总有效率为95.12%（39/41），显著高于氟桂利嗪组的78.05%（32/41），差异有统计学意义（P＜0.05）。结论：控眩止痛汤联合rTMS可缓解VM患者临床症状，降低患者脑血流速度，改善患者脑缺血状态。

关键词：前庭性偏头痛；控眩止痛汤；重复经颅磁刺激；脑血流速度

Release time：2026-03-05

click-through rate：40