Research Progress of Traditional Chinese Medicine in the Treatment of Parkinson's Disease Based on the PI3K/Akt Signaling Pathway
Author：YAN Heyu1, LIU Shuai1, LI Ruijie2, YANG Haolei3, YANG Lijing3
Unit：1.Hebei University of Chinese Medicine, Shijiazhuang Hebei 050000, China; 2.Xinle Hospital of Traditional Chinese Medicine, Xinle Hebei 050700, China; 3.Hebei Provincial Hospital of Traditional Chinese Medicine, Shijiazhuang Hebei 050000, China
Quote：引用：闫禾雨，刘帅，李瑞杰，杨浩雷，杨丽静.基于PI3K/Akt通路探讨中医药治疗帕金森病的研究进展[J].中医药导报,2026,32(2):167-172.
DOI：10.13862/j.cn43-1446/r.2026.02.028
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Abstract：
By reviewing and sorting out relevant literatures, this paper elaborates on the research progress of traditional Chinese medicine (TCM) in treating Parkinson's disease (PD) by regulating the phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt) signaling pathway. The pathogenesis of PD is complex. Western medicine holds that it is closely associated with mitochondrial dysfunction, oxidative stress, neuroinflammation and PI3K/Akt pathway imbalance. In TCM theory, its core pathogenesis is characterized by root deficiency and superficial excess, and limb tremor is caused by liver and kidney deficiency, intermingled phlegm and blood stasis, and other pathogenic factors. Abnormalities of the PI3K/Akt pathway are closely linked to the onset of PD, and affect the progression of PD in terms of cell apoptosis, oxidative stress and inflammatory response. A variety of active components of single Chinese medicinal herbs, TCM compound prescriptions, acupuncture and moxibustion can regulate the PI3K/Akt pathway and its upstream and downstream targets, thereby inhibiting neuronal apoptosis, exerting antioxidant effects and alleviating inflammation. TCM can improve motor and comorbid symptoms of PD patients, and its syndrome differentiation concept is consistent with pathway regulation, which provides a new integrated traditional Chinese and Western medicine approach for the precision treatment of PD.
Key words：Parkinson's disease; traditional Chinese medicine treatment; PI3K/Akt pathway; review
摘要：通过文献阅读与整理，阐述中医药调节磷脂酰肌醇3-激酶/蛋白激酶B（PI3K/Akt）通路治疗帕金森病的研究进展。帕金森病发病机制复杂，西医学认为其与线粒体功能障碍、氧化应激、神经炎症及PI3K/Akt通路失衡密切相关，中医学认为其核心病机为本虚标实，因肝肾亏虚、痰瘀互阻等致肢体震颤。PI3K/Akt通路异常与帕金森病发病紧密相关，在细胞凋亡、氧化应激和炎症反应等方面影响帕金森病的发展。多种单味中药活性成分、中药复方、针灸等可调节PI3K/Akt通路及上下游靶点，抑制神经元凋亡、抗氧化、减轻炎症。中医药能改善患者运动及合并症状，其辨证理念与通路调控契合，为帕金森病精准治疗提供中西医结合新思路。
关键词：帕金森病；中医药治疗；PI3K/Akt通路；综述
Release time：2026-03-05
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