Exploration of the Syndrome Elements and Medication Rules of National Master of Chinese Medicine SHEN Baofan in Treating Coronary Heart Disease Based on Syndrome Differentiation by Prescriptions

Author：WANG Xiaoteng, LIU Fang, LIU Jingjing, HONG Jun

Unit：Affiliated Hospital of Traditional Chinese Medicine, Xinjiang Medical University, Urumqi Xinjiang 830000, China

Quote：引用：王骁腾，刘芳，刘晶晶，洪军.基于以方测证探究国医大师沈宝藩治疗冠心病的证素及用药规律[J].中医药导报,2026,32(2):188-191,233.

DOI：10.13862/j.cn43-1446/r.2026.02.032

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Abstract：Objective: To summarize the syndrome elements and medication rules of National Master of Chinese Medicine SHEN Baofan in the treatment of coronary heart disease (CHD) through data analysis. Methods: R-4.1.2 software was used to explore the distribution of syndrome elements formed by the efficacy of prescriptions and their correlation with symptoms and prescription medications by means of cluster analysis, association rule analysis and frequency analysis. Results: The main syndrome elements were Qi deficiency, blood stasis, Yin deficiency, phlegm-dampness, and Qi stagnation. The syndrome types included Qi-Yin deficiency syndrome (42.6%), Qi deficiency and blood stasis syndrome (26.1%), phlegm obstruction and blood stasis syndrome (19.5%) and Qi stagnation and blood stasis syndrome (11.8%). Common symptoms such as chest tightness, chest pain, poor appetite, poor night sleep, shortness of breath, dry mouth and polydipsia, limb and joint discomfort, and palpitation were closely related to Qi-Yin deficiency syndrome, Qi deficiency and blood stasis syndrome, and phlegm obstruction of blood stasis syndrome. The commonly used Chinese medicines included Chuanxiong (Chuanxiong Rhizoma), Danshen (Salviae Miltiorrhizae Radix), Danggui (Angelicae Sinensis Radix), Chenpi (Citri Reticulatae Pericarpium), Honghua (Carthami Flos), Gegen (Puerariae Radix), Taizishen (Pseudostellariae Radix), Yujin (Curcumae Radix), Shengdihuang (Rehmanniae Radix Exsiccata seu Recens), Zhigancao (Glycyrrhizae Radix cum Liquido Fricta), Gualoupi (Trichosanthis Pericarpium), Zhiqiao (Aurantii Fructus), Chaomaiya (Hordei Fructus Germinatus Frictus), Beishashen (Glehniae Radix) and Huangqi (Astragali Radix). Conclusion: The main syndrome elements of SHEN Baofan's treatment of CHD are Qi deficiency, blood stasis, Yin deficiency, phlegm turbidity and Qi stagnation, and the main syndrome types are Qi-Yin deficiency syndrome and Qi deficiency and blood stasis syndrome. The medication is mainly based on activating blood circulation, eliminating phlegm, tonifying Qi and nourishing Yin, which reflects his academic thoughts of "phlegm and blood stasis are the same source", "phlegm and blood are the same disease", and "phlegm and blood are treated simultaneously".

Key words：coronary heart disease; data mining; syndrome elements; medication rules; SHEN Baofan

摘要：目的：通过数据分析总结国医大师沈宝藩治疗冠心病的证素及用药规律。方法：使用R-4.1.2软件，采用聚类分析、关联规则分析和频数分析等方法，探究方药功效形成的证素分布及其与症状、处方用药的关联性。结果：主要证素为气虚、血瘀、阴虚、痰浊、气滞。证型包括气阴两虚证（42.6%）、气虚血瘀证（26.1%）、痰阻血瘀证（19.5%）和气滞血瘀证（11.8%）。常见症状如胸闷、胸痛、纳差、夜寐差、气短、口干多饮、肢体关节不适、心慌等与气阴两虚证、气虚血瘀证、痰阻血瘀证密切相关。常用中药包括川芎、丹参、当归、陈皮、红花、葛根、太子参、郁金、生地黄、炙甘草、瓜蒌皮、枳壳、炒麦芽、北沙参、黄芪。结论：沈宝藩治疗冠心病的主要证素为气虚、血瘀、阴虚、痰浊、气滞，主要证型为气阴两虚证和气虚血瘀证，用药以活血、祛痰、益气、滋阴为主，体现了“痰瘀同源”“痰瘀同病”“痰瘀同治”的学术思想。

关键词：冠心病；数据挖掘；证素；用药规律；沈宝藩

Release time：2026-03-05

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