Study on Medication Rules of Traditional Chinese Medicine in the Treatment of Ulcerative Colitis Based on Data Mining

Author：LI Yue1, LIU Yaoping1, MIN Li1, GAO Linghui2, HAN Changpeng2, YING Guangyao1

Unit：1.Shanghai Jiading Hospital of Traditional Chinese Medicine, Shanghai 201800, China; 2.Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200080, China

Quote：引用：厉越，刘瑶萍，闵丽，高凌卉，韩昌鹏，应光耀.基于数据挖掘的中医药治疗溃疡性结肠炎的用药规律研究[J].中医药导报,2026,32(2):192-198,214.

DOI：10.13862/j.cn43-1446/r.2026.02.033

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Abstract：

Objective: To explore the medication rules and differences of oral traditional Chinese medicine (TCM) in the treatment of ulcerative colitis (UC). Methods: Relevant literatures on oral TCM for UC published from 2003 to 2024 were retrieved from China National Knowledge Infrastructure (CNKI), Wanfang Data Knowledge Service Platform (Wanfang Data), Chinese Science and Technology Journal Database (CSTJ), Chinese Biological Medicine Database (CBM), PubMed and EmBase. After standardizing the names of TCMs, the medication rules and differences were summarized by analyzing the frequency, efficacy, nature, flavor, meridian tropism and drug compatibility of TCMs. Results: A total of 797 literatures and 898 prescriptions were included. The types of TCMs for UC increased year by year and tended to be stable. The efficacy of TCMs covered a wide range and increased year by year, mainly including heat-clearing TCMs and tonic TCMs. TCMs with warm, cold and neutral nature, as well as bitter, sweet and pungent flavor were widely used, and most of them were attributed to the spleen and stomach meridians. The main drug compatibility included Qi-tonifying and spleen-invigorating TCMs such as Baizhu (Atractylodis Macrocephalae Rhizoma), Fuling (Poria) and Dangshen (Radix Codonopsis Pilosulae), as well as heat-clearing and dampness-draining TCMs such as Huanglian (Rhizoma Coptidis). Common classic formulas included Sijunzi Decoction (四君子汤), Xianglian Pill (香连丸) and Baitouweng Decoction (白头翁汤). Conclusion: From 2003 to 2024, the types and efficacy of oral TCMs for UC increased year by year and tended to be stable. Overall, tonic and heat-clearing TCMs were the main ones. There were few differences in nature, flavor, meridian tropism and drug compatibility. The classic formulas such as Sijunzi Decoction and Xianglian Pill were widely used.

Key words：ulcerative colitis; Chinese medicine; data mining; medication rules

摘要：目的：探讨口服中药治疗溃疡性结肠炎的用药规律及差异。方法：检索中国知网（CNKI）、万方数据知识服务平台（Wanfang Data）、维普中文期刊服务平台（CSTJ）、中国生物医学文献数据库（CBM）、PubMed、EmBase中发表于2003—2024年期间口服中药治疗溃疡性结肠炎的相关文献，对中药名称进行规范化处理后，通过对药物频数、药物功效、性味归经、药物配伍分析并总结用药规律及差异。结果：共纳入797篇文献，898份处方。治疗溃疡性结肠炎的中药种类逐年增加并渐趋平稳，使用的中药功效涵盖范围广且逐年增加，并以清热药和补虚药为主。性温、寒、平和味苦、甘、辛的中药使用较多，且多数中药归于脾、胃经。药物配伍以白术、茯苓、党参等补气健脾药以及黄连等清热利湿药为主。常用经典方有四君子汤、香连丸、白头翁汤。结论：2003—2024年,治疗溃疡性结肠炎的口服中药在种类和功效方面逐年增加并渐趋平稳；总体以补虚、清热药为主；性味归经和配伍方面差异较小；经典名方如四君子汤、香连丸等使用较普遍。

关键词：溃疡性结肠炎；中药；数据挖掘；用药规律

Release time：2026-03-05

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