Analysis of Visualization Mapping for Kidney-Oriented Traditional Chinese Medicine of Depression Based on CiteSpace

Author：SONG Andong1,3, LI Zhantao2, YANG Fan5, LI Guohua1, YUAN Bo1, JIA Menghui2,3, FU Huiling1,2,4

Unit：1.School of Traditional Chinese Medicine, Ningxia Medical University, Yinchuan Ningxia 750000, China; 2.The First People's Hospital of Yinchuan, Yinchuan Ningxia 750000, China; 3.Key Laboratory of Modernization of Ningxia Ethnic Minority Medicine of Ministry of Education, Yinchuan Ningxia 750000, China; 4.The Second Clinical Medical College, Ningxia Medical University, Yinchuan Ningxia 750000, China; 5.Shaanxi Energy Institute, Xianyang Shaanxi 712000, China

Quote：引用：宋安东，李占涛，杨帆，李国花，袁博，贾孟辉，付慧玲.基于CiteSpace分析中药从肾论治抑郁症的可视化图谱[J].中医药导报,2026,32(2):207-214.

DOI：10.13862/j.cn43-1446/r.2026.02.035

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Abstract：Objective: To analyze the evolution path, research hotspots and trends of the theory of "kidney-oriented therapy for depression" in traditional Chinese medicine (TCM), reveal the theoretical development context and research characteristics of this field, and discuss the mechanism of the kidney-brain correlation theory in the prevention and treatment of depression combined with visual knowledge network. Methods: Relevant literatures on "kidney-oriented TCM therapy for depression" included in China National Knowledge Infrastructure (CNKI) from 2005 to 2024 were systematically retrieved. CiteSpace 6.4.R1 was used to conduct cluster analysis of authors, research institutions and core keywords in the literatures, construct co-occurrence network maps, realize multi-dimensional visual analysis, and systematically reveal the academic cooperation mode and theme evolution rules of this field. Results: A total of 252 literatures were included, with the annual number of publications showing an increasing trend and the research dimensions continuously expanding. The research subjects involved 388 researchers and 228 institutions, among which the team of TANG Qisheng from the Third Affiliated Hospital of Beijing University of Chinese Medicine combined with the team of QU Miao from Capital Medical University was the core research force. The cooperation network among institutions was relatively loose, and the cross-regional coordination was insufficient. Keyword analysis extracted 277 high-frequency keywords, forming 13 thematic clusters covering 4 dimensions: treatment strategies, disease classification, syndrome characteristics and research types. A total of 191 Chinese medicine keywords were counted, forming 8 cluster labels. Temporal evolution analysis showed that the research system had expanded from initial clinical observation to the stage of integration with animal experiments and data mining technology, and the research paradigm had undergone an in-depth transformation from basic syndrome classification to molecular action mechanism. Conclusion: The current research on "kidney-oriented TCM therapy for depression" continues to deepen. In the future, it is necessary to strengthen the construction of multi-center collaborative innovation networks, improve the level of evidence-based medicine research, and focus on developing correlation studies on biological markers of kidney-tonifying single drugs for depression and multi-level mechanism analysis. It is suggested to construct a standardized clinical data collection system, promote the transformation of basic research results into clinical application, and provide support for precision diagnosis and treatment and targeted mechanism exploration.

Key words：depression; kidney-oriented therapy; visual analysis; bibliometrics; knowledge mapping

摘要：目的：分析中医药“从肾治郁”理论的演进路径、研究热点及趋势，揭示该领域的理论发展脉络和研究特征，并结合可视化知识网络探讨肾脑相关理论在抑郁症防治中的作用机制。方法：系统检索中国知网数据库中2005—2024年收录的“中医从肾论治抑郁”相关研究文献。通过CiteSpace 6.4.R1工具对文献作者、研究机构及核心关键词进行聚类分析，构建共现网络图谱，实现多维可视化解析，系统揭示该领域学术合作模式与主题演化规律。结果：累计纳入252篇文献，年度发文量呈递增态势且研究维度持续拓展。研究主体涉及388位研究者和228家机构，其中北京中医药大学第三附属医院唐启盛团队联合首都医科大学曲淼团队为核心研究力量。机构间合作网络较为松散，跨区域协同不足。关键词分析提取277个高频关键词，形成13个主题聚类，涵盖治疗策略、疾病分型、证候特征及研究类型4个维度。统计得到中药关键词共191个，形成8个聚类标签。时序演进分析表明，研究体系已从初期临床观察扩展至动物实验与数据挖掘技术融合阶段，研究范式实现基础证候分型向分子作用机制的纵深转变。结论：当前“中药从肾论治抑郁”研究持续深化，后续需强化多中心协同创新网络建设，提升循证医学研究等级，重点开发补肾单药治疗抑郁的生物学标志物关联性研究及多层次机制解析。建议构建标准化临床数据采集体系，推动基础研究成果向临床应用转化，为精准诊疗及靶向机制探索提供支撑。

关键词：抑郁；从肾论治；可视化分析；文献计量学；知识图谱

Release time：2026-03-05

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