Evidence Map of Clinical Research on Treatment of Arrhythmia Combined with Anxiety and Depression with Traditional Chinese Medicine

Author：WU Chaonan1, MA Zhen2, WANG Shuai1, HUANG Na1, HU Jiale1, WANG Chao3, LIU Yilong2, DU HongSen2

Unit：1.The Fifth Clinical Medical College of Shaanxi University of Chinese Medicine, Xi'an Shannxi 710021, China; 2.Xi'an Hospital of Traditional Chinese Medicine, Xi'an Shannxi 710021, China; 3.Dongfang Hospital, Beijing University of Chinese Medicine, Beijing 100078, China

Quote：引用：吴超楠，马振，王帅，黄娜，胡嘉乐，王超，刘毅龙，杜泓森.中医药治疗心律失常合并焦虑抑郁状态的临床研究证据图[J].中医药导报,2026,32(2):215-224.

DOI：10.13862/j.cn43-1446/r.2026.02.036

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Abstract：

Objective: To sort out the clinical studies on the treatment of arrhythmia complicated with anxiety and depression by traditional Chinese medicine (TCM) with the method of evidence mapping, so as to understand the evidence distribution in this field. Methods: Relevant literatures on the treatment of arrhythmia complicated with anxiety and depression by TCM were retrieved from China National Knowledge Infrastructure (CNKI), Chinese Biomedical Literature Service System (SinoMed), China Science and Technology Journal Database (CSTJ), Wanfang Data Knowledge Service Platform (Wanfang Data), PubMed, Embase and Cochrane Database from the establishment of the databases to April 2025. The distribution characteristics of evidence in this field were presented in a combination of text and pictures to realize visual display of data. Results: A total of 123 randomized controlled trial literatures, 2 non-controlled trial literatures and 1 meta-analysis literature were finally included. It involved 13 classic prescriptions, 8 proprietary Chinese medicines, 57 self-made formulas, and various TCM external treatment methods. Among the classic prescriptions, Guizhi Gancao Longmu Muli Decoction (桂枝甘草龙骨牡蛎汤) had the most literatures, while among proprietary Chinese medicines, Shensong Yangxin Capsule (参松养心胶囊) and Wenxin Granule (稳心颗粒) had the highest frequency. The number of publications in this field is relatively low but overall showing an upward trend. Provinces with large populations or economically developed regions have relatively high publication volumes. LI Feize has the highest number of published articles and has less cross team collaboration. The sample size is mostly concentrated in 60-90 cases, and the intervention duration is mostly 4 weeks. The proportion of literatures with initial age ≤20 years old is 38.4%. The most common arrhythmia type is ventricular premature beat, and the most common combined disease in studies of arrhythmia complicated with other diseases is coronary heart disease. The most included TCM syndrome type is Qi-Yin deficiency syndrome. Only 29.6% of the literatures obtained ethical approval. The outcome indicators are mainly divided into total effective rate, electrocardiogram indicators, anxiety or depression emotional indicators, symptomatic efficacy, cardiac function indicators, safety indicators, etc. The quality of included interventional study literatures and meta-analysis is generally not high. Conclusion: TCM can further improve the prognosis of arrhythmia and quality of life by effectively reducing patients' anxiety and depression. In the future, it is urgent to carry out large-sample, multi-center and standardized clinical trials to obtain high-quality evidence-based medicine evidence, so as to provide scientific basis for the clinical application of TCM in the treatment of arrhythmia complicated with anxiety and depression.

Key words：arrhythmia; anxiety and depression; traditional Chinese medicine; evidence mapping

摘要：目的：以证据图的方法梳理中医药治疗心律失常合并焦虑抑郁的临床研究，了解该领域的证据分布。方法：检索中国知网（CNKI）、中国生物医学文献服务系统（SinoMed）、维普中文期刊服务平台（CSTJ）、万方数据知识服务平台（Wanfang Data）、PubMed、Embase、Cochrane数据库中中医药治疗心律失常合并焦虑抑郁的相关文献，检索时限均从建库至2025年4月。通过图文并茂的方式呈现该领域的证据分布特征，实现数据的可视化展示。结果：最终纳入123篇随机对照试验文献，2篇非对照试验文献，1篇Meta分析文献。共涉及经方13种、中成药8种、自拟方57种，以及多种中医外治法。经方中桂枝甘草龙骨牡蛎汤相关文献发文较多，中成药则以参松养心胶囊、稳心颗粒出现的频率最高。该领域发文量较少但总体呈上升趋势；人口大省或经济发达地区发文量相对较高；发文量最多的为李飞泽，跨团队合作较少；样本量多集中在60～90例；干预时长多分布在4周；起始年龄≤20岁的文献占比为38.4%；心律失常类型以室性早搏最多，心律失常合并其他疾病的研究中以冠心病最多；纳入的中医证型以气阴两虚证最多；获得伦理批准的文献仅占29.6%；结局指标主要分为总有效率、心电图指标、焦虑或抑郁情绪指标、症状疗效、心功能指标、安全性指标等；纳入的干预性研究文献及Meta分析整体质量均不高。结论：中医药可通过有效减轻患者的焦虑抑郁情绪，从而进一步改善其心律失常预后，提高生活质量。未来亟需开展大样本、多中心、标准化的临床试验，以获取高质量的循证医学证据，为中医药治疗心律失常合并焦虑抑郁的临床应用提供科学依据。

关键词：心律失常；焦虑抑郁；中医药；证据图

Release time：2026-03-05

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